Urinary hCG Trajectories and Miscarriage Risk After Embryo Transfer

A prospective cohort study of 207 women undergoing embryo transfer at Hebei Maternity Hospital. Urinary human chorionic gonadotropin (hCG) levels were measured daily from day 7 post-transfer for up to 51 days to identify dynamic trajectories associated with early miscarriage risk. The dataset was created by Jing Wang and is licensed under CC-BY-4.0.

Use Cases

• Predict miscarriage risk based on urinary hCG trajectory patterns.
• Validate latent class trajectory modeling for biomarker time-series data.
• Assess the predictive performance of clinical models using ROC, DCA, and calibration curves.
• Investigate the association between specific hCG trajectory groups (Low-Slow, Low-Steady, High-Steady) and adverse pregnancy outcomes.

Strengths

• Prospective cohort design with 207 participants provides a structured clinical study foundation.
• Daily quantitative hCG measurements over a period of up to 51 days allow for detailed trajectory analysis.
• Results include specific odds ratios (e.g., aOR=38.11 for Low-Slow trajectory) and model performance metrics (AUC=0.857).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a single hospital in Hebei, China, which may limit generalizability to other populations.

Provenance

Source

figshare

Collection Method

Prospective cohort study with daily urinary hCG measurements using a latex immunochromatography assay.

Time Range

Measurements taken from day 7 to day 51 post embryo transfer.

Freshness

Last updated 2026-06-04 04:27:39; freshness should be verified.

Geography

Data collected at Hebei Maternity Hospital in China.