UK Biobank Nutrient Risk Score and Rheumatoid Arthritis Incidence

Data from a prospective cohort study of 161,725 UK Biobank participants, authored by Aimin Wang and last updated in May 2026. The study investigated the association between a data-driven nutrient risk score (NRS) and incident rheumatoid arthritis over a median follow-up of 13.4 years, during which 1,756 participants developed RA. It also examined the modifying effect of genetic susceptibility and the mediating role of obesity.

Use Cases

• Modeling the association between a composite nutrient risk score and disease incidence based on the study's findings.
• Investigating gene-environment interactions in rheumatoid arthritis risk based on the stratified genetic risk analysis.
• Assessing the mediating role of obesity indicators in the link between diet and autoimmune disease.
• Conducting risk stratification for rheumatoid arthritis based on combined nutritional and genetic profiles.

Strengths

• Includes data from a large prospective cohort of 161,725 participants.
• Features a long median follow-up period of 13.4 years.
• Analysis includes multiple statistical methods (Cox models, propensity score weighting, mediation analysis).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic and demographic bias inherent to the UK Biobank cohort.

Provenance

Source

UK Biobank

Collection Method

Prospective cohort study; nutrients were selected using a LASSO-Cox model.

Time Range

Median follow-up of 13.4 years (specific start/end dates not provided).

Freshness

Last updated 2026-05-26 04:37:06; freshness should be verified.

Geography

United Kingdom