Genetic and Blood Group Associations with MIS-C in Italian Children

A cohort of 18 Italian children with MIS-C or Kawasaki-like disease was analyzed for genetic risk factors. The study compares ABO blood group allele frequencies and rare variants in 207 immune-related genes against control groups of 79 children and 2,848 adults. The data was published by Luisa Ronzoni on figshare in April 2026.

Use Cases

• Assessing the association of blood group B alleles with MIS-C risk based on odds ratios reported in the description
• Investigating rare damaging variants in immune-related genes as potential contributors to MIS-C
• Comparing genetic susceptibility profiles between MIS-C and Kawasaki–SARS-CoV-2-related disease subphenotypes

Strengths

• Includes a focused cohort of 12 MIS-C and 6 Kawasaki-like disease patients
• Compares patient data against control groups of 79 children and 2,848 adults
• Analyzes variants across a panel of 207 immune-related genes

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is small (428.1 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Genetic analysis of an Italian patient cohort, including whole exome sequencing.

Freshness

Last updated 2026-04-10 06:02:07; freshness should be verified

Geography

Italy