Data_Sheet_1_Association of gut microbiota with lactose intolerance and coeliac disease: a

A Mendelian randomization study investigating causal links between gut microbiota and two nutrient malabsorption disorders. The analysis used genome-wide association study data and identified specific bacterial families and genera as protective or risk factors for lactose intolerance and coeliac disease. The dataset, 919.3 KB in size, was authored by Zongze Han and last updated on 2026-04-28.

Use Cases

• Identifying potential probiotic or therapeutic targets based on protective bacterial taxa identified for lactose intolerance.
• Investigating causal risk factors for coeliac disease based on the bacterial genera flagged as risk factors.
• Validating gut microbiome-disease hypotheses using Mendelian randomization methods described in the study.
• Exploring the genetic basis of host-microbiome interactions in common digestive disorders.

Strengths

• Results are based on Mendelian randomization, a method for causal inference, as described in the materials.
• Robustness of findings was confirmed through multiple sensitivity analyses including Cochrane’s Q statistic and MR-PRESSO, as stated in the description.
• The dataset is shared under a CC-BY-4.0 license, permitting broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description notes that further experimental investigations are required to elucidate specific underlying mechanisms.

Provenance

Source

figshare

Collection Method

Analysis of genome-wide association study data using Mendelian randomization.

Freshness

Last updated 2026-04-28 15:17:55; freshness should be verified.