UK Biobank Organ Dysfunction Trajectories and Cardiovascular Event Risk

457,675 participant records from the UK Biobank study linking obesity classifications to major adverse cardiovascular events (MACE). The data, authored by Yohwan Lim and last updated in May 2026, was used to evaluate multi-organ dysfunction trajectories over consecutive 2-year periods against a composite endpoint of ischemic heart disease, stroke, and fatal cardiovascular disease.

Use Cases

• Compare BMI-based versus clinically-defined obesity classifications for cardiovascular risk prediction.
• Model the association between persistent organ dysfunction trajectories and incident MACE.
• Assess the risk discrimination improvement from incorporating longitudinal organ dysfunction assessment.

Strengths

• Large cohort of 457,675 UK Biobank participants.
• Longitudinal design tracking organ dysfunction over consecutive 2-year periods.
• Analysis includes adjusted hazard ratios (aHR) with 95% confidence intervals.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is contained in a DOCX file (128.9 KB), suggesting it is likely a summary or results document rather than raw data tables.

Provenance

Source

UK Biobank

Collection Method

Analysis of participant records using Cox proportional hazards models.

Time Range

Follow-up period up to 10 years after an index date.

Freshness

Last updated 2026-05-14 04:30:07; freshness should be verified.

Geography

United Kingdom