Naples Prognostic Score and Parkinson Disease Risk in UK Biobank Cohort

A prospective cohort study of 317,035 UK Biobank participants investigates the association between the Naples prognostic score (NPS) and Parkinson disease risk. The dataset, authored by Zhiqiang Xu and last updated in April 2026, includes data from participants recruited between 2006 and 2010, with a median follow-up of 13.94 years. It reports hazard ratios for PD risk based on NPS scores derived from serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio.

Use Cases

• Modeling Parkinson disease risk based on the Naples prognostic score (NPS) derived from inflammatory and nutritional biomarkers.
• Analyzing dose-response relationships between systemic immune-metabolic status and disease incidence.
• Validating the NPS as a readily available marker for clinical risk stratification in prospective cohort studies.

Strengths

• Large prospective cohort of 317,035 participants from the UK Biobank.
• Long median follow-up period of 13.94 years, tracking 2,298 incident PD cases.
• Clear statistical results showing a dose-response relationship, with hazard ratios provided for different NPS scores.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 208.2 KB PDF, which is a very small summary document rather than a raw dataset.

Provenance

Source

UK Biobank participants recruited in 2006–2010.

Collection Method

Cox proportional hazards models with multivariable adjustment applied to prospective cohort data.

Time Range

Baseline recruitment 2006-2010, follow-up through 31 December 2022.

Freshness

Last updated 2026-04-30 05:38:43; freshness should be verified.

Geography

United Kingdom (UK Biobank).