CHG Index and MASLD Risk in Chinese Adults: 5-Year Retrospective Cohort

A 5-year retrospective cohort study of 6,274 individuals from a Chinese hospital health assessment program explores the association between the CHG index and Metabolic-Associated Steatotic Liver Disease risk. The analysis uses Cox regression and ROC analysis, finding a non-linear relationship with an inflection point at CHG=5.42.

Use Cases

• Analyze the non-linear association between the CHG index and MASLD risk using Cox regression with restricted cubic splines.
• Evaluate the predictive performance of the CHG index for 5-year MASLD risk via ROC curve analysis, comparing AUC values to TyG and FLI indicators.
• Investigate hazard ratios (HR) for MASLD per 0.1-unit increase in CHG, segmented by the identified inflection point of 5.42.
• Conduct time-dependent ROC analysis to assess CHG's predictive AUC stability over a 2.0–5-year period.

Strengths

• Cohort of 6,274 individuals provides a substantial sample for longitudinal health analysis.
• 5-year retrospective study period (2018-2023) enables analysis of risk over time.
• Statistical analysis includes multivariable Cox regression, non-linear modeling, and ROC curve evaluation with reported AUC values.

Limitations

• Dataset is described in a 426.8 KB DOCX file, indicating the underlying tabular data is not directly accessible or structured for machine learning.
• Study population is from a single hospital in China, limiting geographic and demographic generalizability.
• Specific column names, row counts for variables, and raw data samples are unavailable, hindering direct computational use.

Provenance

Source

Health assessments at Shenzhen Kuichong People’s Hospital.

Collection Method

Retrospective cohort analysis.

Time Range

2018 to 2023.

Freshness

Data covers assessments from 2018 to 2023; metadata was last updated in March 2026.

Geography

China (Shenzhen).