TyG-GGT Index and Diabetes Risk: A Retrospective Cohort Study of 8,678 Participants

From 2018 through 2023, a retrospective cohort study enrolled 8,678 participants who underwent health screenings at Kuichong People’s Hospital in Shenzhen. The research investigates the association between the TyG-GGT index, a novel insulin resistance marker, and incident diabetes mellitus risk. The dataset, authored by Yajing Gao and last updated in 2026, includes results from Cox regression and ROC curve analyses.

Use Cases

• Assessing the predictive capacity of the TyG-GGT index for diabetes risk based on ROC curve analysis results mentioned in the description
• Investigating non-linear relationships between insulin resistance markers and disease incidence based on the described threshold analysis
• Conducting sensitivity and subgroup analyses to verify the stability of clinical associations as described in the study methods
• Comparing the discriminatory performance of TyG-GGT against other markers like TG, GGT, FPG, and TyG based on the reported AUC values

Strengths

• Includes data from 8,678 participants, providing a substantial cohort for analysis.
• Study employs multiple analytical methods, including Cox regression and time-dependent ROC analysis over a 5-year prediction horizon.
• Results show a specific hazard ratio (HR 1.116 per 50-unit increase) and an identified inflection point at a TyG-GGT value of 380.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain modeling tasks.
• Data is sourced from a single hospital in Shenzhen, which may reflect geographic bias.

Provenance

Source

Kuichong People’s Hospital in Shenzhen

Collection Method

Retrospective cohort investigation using health screening data.

Time Range

2018-2023

Freshness

Last updated 2026-04-21 04:22:51; freshness should be verified.

Geography

Shenzhen, China