Retinal Measurements and Cognitive Functions in 125 Cerebral Small Vessel Disease Patients

A collection of measurements from 125 patients with cerebral small vessel disease, linking multimodal retinal imaging parameters to cognitive function scores. It includes retinal structural and vascular features, such as peripapillary retinal nerve fibre layer thickness and vessel densities of the superficial and deep retinal capillary plexuses, assessed against cognitive domains measured by the Mini-Mental State Examination.

Use Cases

• Train a model to predict Mini-Mental State Examination scores from vessel densities in the whole macular superficial retinal capillary plexus.
• Analyze associations between peripapillary retinal nerve fibre layer thickness and specific cognitive domain scores like visuospatial function.
• Build a classifier to screen for cognitive impairment using vessel density features from the perifoveal superior superficial retinal capillary plexus.
• Investigate the correlation between the central retinal arteriolar equivalent/central retinal venular equivalent ratio and general cognitive decline.

Strengths

• Includes data from 125 clinically assessed patients with cerebral small vessel disease.
• Features are derived from multimodal retinal imaging, including structural thickness and vascular density measurements.
• Cognitive assessment covers multiple domains: general cognition, memory, visuospatial space, attention and numeracy, language, and orientation.
• Uses a fully automated vessel segmentation and parameter calculation method for feature quantification.

Limitations

• Small sample size of 125 patients limits statistical power and generalizability of findings.
• Cross-sectional study design prevents inference of causal relationships between retinal parameters and cognitive decline.
• Patient cohort is specific to cerebral small vessel disease, which may not be representative of other causes of cognitive impairment.

Provenance

Source

Meizi Wang via figshare.

Collection Method

Cross-sectional study enrolling 125 patients with CSVD-related white matter hyperintensities; multimodal retinal imaging and cognitive assessments were performed.

Freshness

Last updated 2026-03-20.