Cord Blood Biomarkers and Infant Colic Associations from Boston Cohort

Project Viva, a pre-birth cohort in the greater Boston, MA area, provided data for this study. The dataset likely contains cord blood biomarker measurements for 405 infants born between 1999 and 2002, analyzed for associations with parent-reported colic and excessive crying at 6 months. The exploratory research was conducted by Elisabeth M. Simonin.

Use Cases

• Identify candidate biomarkers for infant colic based on cord blood trans fatty acid levels.
• Explore microbial dysbiosis links to excessive crying using Gammaproteobacteria signature data.
• Assess the lack of association between colic and a range of inflammatory and immune system biomarkers.
• Investigate potential predictors for adverse health outcomes like atopy and migraines based on early biomarker profiles.

Strengths

• Includes data from 405 participants with cord blood biomarker measurements.
• Focuses on a specific cohort (Project Viva) from a defined geographic region (Boston).
• Examines associations with both colic and excessive crying without colic as distinct conditions.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic/temporal bias inherent to a single cohort from 1999-2002.

Provenance

Source

figshare

Collection Method

Data extracted from Project Viva, a pre-birth cohort study.

Time Range

1999-2002

Geography

Greater Boston, MA area