ATG16L1-OPTN Gene Expression Signature for Acute Myeloid Leukemia Survival

A research dataset from figshare, authored by Alexandra Teixeira and last updated in May 2026, explores a novel two-gene prognostic signature in acute myeloid leukemia. The work correlates the expression of autophagy-related genes ATG16L1 and OPTN with overall survival outcomes. Analysis was validated in two larger cohorts, BEATAML2 and TCGA LAML, reinforcing the signature's clinical relevance.

Use Cases

• Developing prognostic models for AML patient survival based on the ATG16L1-OPTN gene expression signature.
• Validating the association of autophagy-related genes with clinical outcomes in independent AML cohorts.
• Comparing the prognostic power of autophagy-related genes against known AML-related genes as described in the research.

Strengths

• The prognostic signature was validated in two larger cohorts (BEATAML2 and TCGA LAML), suggesting external reliability.
• The dataset is associated with a specific research finding linking a two-gene signature (ATG16L1-OPTN) to overall survival in AML.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is relatively small at 1.2 MB, which may indicate limited scope.

Provenance

Source

figshare

Collection Method

Likely contains gene expression data and clinical survival outcomes from research analysis.

Freshness

Last updated 2026-05-05 07:30:49; freshness should be verified.