Data Sheet 1_Atypical hemolytic uremic syndrome in a patient with thalassemia and a CFH ge

Jing Wu authored a case report published on figshare on 2026-04-27. The report details a single case of pregnancy-associated atypical hemolytic uremic syndrome (aHUS) in a patient with thalassemia and a complement factor H (CFH) gene mutation. It describes the diagnostic and therapeutic approach, including treatment with plasmapheresis, hemodialysis, eculizumab, and luspatercept.

Use Cases

• Study the co-occurrence and potential interaction of genetic mutations and hematological disorders based on the described case of thalassemia with a CFH gene mutation.
• Analyze treatment strategies for complex, multi-factorial medical cases based on the described use of plasmapheresis, hemodialysis, eculizumab, and luspatercept.
• Investigate the 'two-hit' mechanism in complement cascade amplification based on the described hypothesis involving hemoglobin release from fragmented erythrocytes.
• Review clinical outcomes of C5 inhibitor therapy in specific patient subgroups based on the described case and follow-up period.

Strengths

• The dataset is a detailed clinical case report with a specific focus on a rare co-occurrence of conditions.
• It is published under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.
• The report includes a specific therapeutic regimen and patient outcome from the follow-up period.

Limitations

• The dataset is a single case report (n=1), limiting statistical power and generalizability.
• Row count and column-level documentation are absent; the data is presented in narrative form within a PDF.
• The file is 1.4 MB, indicating a small-scale, single-document dataset.

Provenance

Source

figshare, author Jing Wu.

Collection Method

Clinical case documentation.

Freshness

Last updated 2026-04-27 13:33:43; freshness should be verified.