Multi-Omics Study of B Cell-Mediated Immune Surveillance in Occult Breast Cancer

A research paper analyzing the immune landscape of occult breast cancer (OBC) using multi-omics approaches. The study integrates survival data from the SEER database (n=12,162), quantitative proteomics, bulk transcriptomics, and single-cell RNA sequencing. It was authored by Junjie Liu and last updated on 2026-04-17.

Use Cases

• Validate survival outcomes based on SEER database analysis with propensity score matching
• Characterize molecular features based on quantitative proteomic profiling
• Assess immune cell infiltration and intercellular communication based on bulk and single-cell transcriptomics

Strengths

• Integrates multiple data modalities: survival analysis, proteomics, bulk and single-cell transcriptomics
• Validates findings using a large external cohort from the SEER database (n=12,162)
• Published under a permissive CC-BY-4.0 license

Limitations

• The primary data file is a 1.8 MB PDF; underlying raw datasets are not directly accessible
• Row count and column-level documentation for any underlying data are unknown
• Findings are described as exploratory and pending functional validation in larger cohorts

Provenance

Source

figshare

Collection Method

Multi-omics study integrating public database analysis (SEER) with original molecular profiling

Freshness

Last updated 2026-04-17 05:22:12