Baicalin Anti-Cancer Mechanism Study Document

Colorectal cancer is the third most diagnosed and second deadliest cancer globally. This document details a study on baicalin, a flavonoid that inhibits hexokinase II, suppresses colorectal cancer cell proliferation, and promotes M1 polarization of tumor-associated macrophages. The 710.3 KB document, authored by Dong-hui Bai and last updated in May 2026, is shared under a CC-BY-4.0 license.

Use Cases

• Study the molecular mechanism of HK2 inhibition based on the described in vitro and in vivo experiments.
• Analyze the link between glycolysis inhibition and immune activation based on the cGAS/STING pathway findings.
• Investigate flavonoid compounds as potential cancer therapeutics based on the study of baicalin.
• Model drug-protein interactions based on the molecular docking and dynamics simulations mentioned.

Strengths

• The study describes a multi-method validation approach, including molecular docking, DARTS, CETSA, and an MC38 syngeneic tumor model.
• The document is shared under a permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• The dataset is a single 710.3 KB DOCX file, indicating a limited scope focused on one study's findings.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for structured data analysis.

Provenance

Source

figshare

Collection Method

Likely contains research data and analysis from a laboratory study.

Freshness

Last updated 2026-05-04 05:32:47; freshness should be verified.