Data Sheet 1_Benzofuran compound from Sophora tonkinensis Gagnep suppresses nasopharyngeal

Peiying Wu published a research article on figshare in April 2026 detailing the isolation and anti-cancer effects of a benzofuran compound (ABF) from Sophora tonkinensis. The study includes molecular dynamics simulation results, in vitro cell line (CNE1, CNE2) activity data with IC50 values, and in vivo tumor inhibition rates from a nude mouse xenograft model. The 3.5 MB PDF provides evidence that ABF inhibits cancer growth via the PI3K/AKT/mTOR pathway.

Use Cases

• Validate molecular docking and dynamics simulation protocols based on the described ABF-protein binding affinity data.
• Benchmark in vitro anti-proliferative activity against nasopharyngeal carcinoma cell lines using the reported IC50 values.
• Study the role of the PI3K/AKT/mTOR pathway in cancer based on the Western blot and PCR analysis results.
• Compare tumor inhibition efficacy of natural compounds using the in vivo xenograft model results showing ~46% inhibition rates.

Strengths

• Includes specific quantitative results such as a 10-fold lower 48-h IC50 value for ABF compared to the crude extract.
• Reports tumor inhibition rates of 46.59% and 45.71% from an in vivo nude mouse xenograft model.
• Provides multi-modal evidence combining molecular dynamics simulation, in vitro assays, and in vivo experiments.

Limitations

• The dataset is a single 3.5 MB PDF; underlying raw numerical or image data files are not separately provided.
• Row count and column-level documentation are absent; data must be extracted manually from the publication.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, authored by Peiying Wu.

Collection Method

Data generated through targeted compound isolation, HPLC fingerprinting, molecular dynamics simulations, and in vitro/in vivo biological assays.

Freshness

Last updated 2026-04-23 05:34:43; freshness should be verified.