Data Sheet 1: Preclinical Data on Berbamine's Synergistic Effect with Chemotherapy in HCC

Data Sheet 1_Berbamine sensitizes hepatocellular carcinoma to chemotherapy by inhibiting autophagy via modulating SIRT1-mediated acetylation.pdf contains experimental data from a study investigating the natural alkaloid Berbamine as a chemosensitizer. The 1.3 MB PDF, authored by Qin Peng and last updated May 14, 2026, includes results from in vitro assays (CCK-8, colony formation, apoptosis) and an in vivo H22 xenograft mouse model, detailing the mechanism of autophagy inhibition via the SIRT1-TFEB axis.

Use Cases

• Validate synergistic drug effects based on in vitro combination assays with 5-FU, Sorafenib, and Paclitaxel.
• Study autophagy inhibition mechanisms based on LC3-II and p62 accumulation data.
• Investigate the SIRT1-TFEB regulatory axis based on protein expression and NAD+/NADH ratio measurements.
• Assess in vivo efficacy of combination therapy based on H22 xenograft mouse model results.

Strengths

• Data is derived from multiple experimental assays including CCK-8, colony formation, and apoptosis tests.
• Includes both in vitro cell line data and in vivo data from an H22 xenograft mouse model.
• Mechanistic investigation covers protein expression, lysosomal function, and transcription factor activity.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific cell lines and animal models used in preclinical research.

Provenance

Source

Qin Peng via figshare.

Collection Method

Experimental data from laboratory assays and animal models.

Freshness

Last updated 2026-05-14 05:34:38; freshness should be verified.