Bioactive Glass S53P4 Cream Antimicrobial Efficacy Against Pathogens and Biofilms

A 92.2 KB PDF research article details the antimicrobial properties of a novel bioactive glass S53P4 cream. The study, authored by Deeksha Rajkumar and last updated in May 2026, characterizes the cream's ability to kill planktonic Staphylococcus aureus and its biofilms, as well as a panel of multidrug-resistant ESKAPE pathogens. Results include time-kill assays, biofilm reduction data, and efficacy evaluation in a cadaver mouse bone defect model.

Use Cases

• Evaluating novel antimicrobial materials based on ion release and pH change data.
• Studying biofilm eradication strategies for Staphylococcus aureus based on time-dependent bactericidal assays.
• Screening compound efficacy against multidrug-resistant ESKAPE pathogens based on eluate testing results.
• Modeling antimicrobial application in bone defects based on the cadaver mouse model findings.

Strengths

• Data includes time-dependent measurements of elemental ion release (silicon, sodium, calcium, phosphorous) and pH changes.
• Antimicrobial efficacy is tested against a defined panel including the ESKAPE pathogens, colistin-resistant E. coli, and Candida species.
• Application method and efficacy are evaluated in a specific biological model (cadaver mouse bone defect).

Limitations

• The primary data format is a PDF research article; underlying raw experimental data is not directly provided.
• Row count and column-level documentation for any underlying tabular data are unknown.
• The dataset's scale is limited to the specific experiments described in the 92.2 KB document.

Provenance

Source

figshare

Collection Method

Experimental laboratory study involving time-kill assays, biofilm assays, and ion release measurements.

Freshness

Last updated 2026-05-04 08:03:53