Environmental E. coli Strains with Colistin Resistance and Oxidant Tolerance

A 2026 study by Asmaa Al-Mesaifri characterizes several Escherichia coli strains isolated from mixed wastewater. The strains show varying resistance to the last-resort antibiotic colistin, with IC50 values ranging from 6.5 to 27.3 μg/mL, and also display resistance to ultraviolet radiation and hydrogen peroxide. Whole genome sequencing data suggests missense mutations in DNA repair genes may contribute to the observed oxidant tolerance.

Use Cases

• Analyzing the correlation between mcr-1 gene presence and colistin resistance levels based on reported IC50 values.
• Investigating cross-resistance patterns to multiple antibiotic classes, including ciprofloxacin and tetracycline, as described.
• Studying the genetic basis of oxidant tolerance based on reported missense mutations in DNA repair genes.
• Modeling the spread of plasmid-borne resistance genes from environmental sources into other sectors.

Strengths

• Includes specific quantitative measurements for colistin resistance (IC50 values ranging 6.5–27.3 μg/mL).
• Describes resistance profiles to multiple, distinct antibiotic classes (e.g., ciprofloxacin, sulfamethoxazole).
• Links phenotypic oxidant tolerance to genomic data from whole genome sequencing.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (23.7 KB), indicating limited scope.

Provenance

Source

Asmaa Al-Mesaifri via figshare.

Collection Method

E. coli strains were isolated from mixed wastewater and characterized biochemically and genomically.

Freshness

Last updated 2026-06-02 22:02:21.