Biofilm-targeted Liposomal Curcumin Delivery System for Anti-caries Therapy

A 939.5 KB PDF authored by Yao Chen describes a pH-responsive liposomal curcumin delivery system for caries prevention. The study includes physicochemical characterization, biocompatibility assays, and antibacterial efficacy tests in vitro, ex vivo, and in vivo using a rat caries model. The document was last updated on April 29, 2026.

Use Cases

• Analyze the efficacy of pH-responsive liposomes for biofilm penetration based on the described physicochemical characterization.
• Evaluate biocompatibility of novel drug delivery systems based on the CCK-8 assays, hemolysis tests, and Live/Dead cell staining methods.
• Study the impact of light-activated reactive oxygen species on bacterial viability based on the in vitro antibacterial efficacy results.
• Assess shifts in oral microbiome composition toward a less dysbiotic profile based on the 16S rRNA sequencing results from the rat model.

Strengths

• The study includes a multi-faceted evaluation with physicochemical characterization, biocompatibility assays, and antibacterial efficacy tests.
• An in vivo rat caries model was used to assess therapeutic efficacy, reducing lesion depth by approximately 50%.
• The document is licensed under CC-BY-4.0, facilitating open reuse.

Limitations

• The dataset is a single PDF document; the underlying raw experimental data is not provided.
• Row count and column-level documentation are absent; data structure must be inferred from the text.
• The file size is 939.5 KB, indicating a limited scope of data.

Provenance

Source

figshare

Collection Method

The data likely originates from a laboratory study involving the development and testing of a liposomal delivery system.

Freshness

Last updated 2026-04-29 05:57:57; freshness should be verified.