Mouse Model Data on Influenza Severity by Sex and Obesity Status

A study of 21 days post-infection in C57BL/6J mice fed high-fat or low-fat diets and infected with high or low doses of H1N1 influenza A virus. The dataset, authored by Saurav Pantha and last updated in April 2026, includes measurements of survival, lung virus titers, histopathology, cellular infiltration, and cytokine induction. It was published on figshare under a CC-BY-4.0 license.

Use Cases

• Modeling survival outcomes based on biological sex and obesity status mentioned in the description
• Analyzing correlations between inflammatory markers and disease severity described in the results
• Comparing lung pathology and immune cell infiltration across different infection doses and diet groups
• Investigating temporal dynamics of cytokine induction over a 21-day infection period

Strengths

• Data includes a 21-day longitudinal follow-up for morbidity
• Experimental design compares four key variables: sex, obesity status, and two infection doses
• Measures multiple biological endpoints: virus titers, histopathology, cellular infiltration, and cytokines

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is derived from a controlled mouse model; direct applicability to human populations may be limited

Provenance

Source

figshare

Collection Method

Laboratory experiment with C57BL/6J mice inoculated with mouse-adapted A/California/04/2009 H1N1 IAV.

Time Range

Study period covers 21 days post-infection.

Freshness

Last updated 2026-04-10 05:57:52

Geography

Laboratory setting; geographic coverage is not specified.