Data Sheet 1: Bivalent VLP Vaccine Candidate Data for Pre-Erythrocytic Malaria Immunity

A data sheet describing experimental results for bivalent virus-like particle vaccine candidates targeting Plasmodium falciparum malaria antigens SPECT1 and CSP. The document, authored by Gulbuse Turan and last updated in May 2026, details the engineering, immunogenicity, and protective efficacy of these candidates in a mouse challenge model. The file is 3.1 MB and available under a CC-BY-4.0 license.

Use Cases

• Compare antibody titers and protective efficacy between monovalent and bivalent VLP constructs based on the described experimental results.
• Analyze the correlation between NANP-specific IgG response and blood stage parasite load as mentioned in the results.
• Evaluate the impact of different adjuvant formulations (Matrix-M, LMQ, SMNP) on humoral responses and protection for the selected N4 candidate.
• Assess the in vivo co-display of PfSPECT-1 and CSP epitopes on VLPs based on the described IgG response data.

Strengths

• The dataset is associated with a specific, peer-reviewed research project described in detail, including methods and results.
• The data is licensed under CC-BY-4.0, allowing for broad reuse and sharing.
• The file includes a last updated timestamp (2026-05-14 05:43:26), providing a recency indicator.

Limitations

• The data is contained within a DOCX file (3.1 MB); the underlying structured data (e.g., numerical results, raw measurements) is not directly accessible as a machine-readable table.
• Row count and column-level documentation are unknown, which limits suitability assessment for quantitative analysis.
• The description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, author Gulbuse Turan.

Collection Method

Likely contains experimental data generated from a preclinical vaccine study in mice.

Freshness

Last updated 2026-05-14 05:43:26; freshness should be verified.