Data Sheet 1_Boolean network and meshless simulations for the comparison of transport and reaction mechanisms arising in one-short tri-exponential and uniform infusion electrochemotherapeutic treatments.pdf

4.7 MB PDF contains in silico findings on transport and reaction mechanisms in electrochemotherapy. The work compares two pharmacokinetic profiles (TPK and UPK) across permutations of electric field magnitude (E) and bloodstream velocity (λinl). Simulations were conducted using a meshless code and a Boolean model to analyze concentration ratios.

Use Cases

• Compare spatio-temporal evolution of extracellular, free intracellular, and bound intracellular concentration ratios between TPK and UPK pharmacokinetic profiles.
• Analyze the influence of electric field magnitude (E) on the uniformity of transmembrane transport in radial and axial directions.
• Investigate how bloodstream velocity (λinl) affects the radial homogeneity and axial uniformity of transport mechanisms.
• Examine the interaction between RTMs (extravasation, perfusion, transport, association/dissociation, drainage) for specific combinations of E and λinl.

Strengths

• Simulations test multiple specific parameter combinations: three levels of electric field magnitude (E: 0 kV/m, 46 kV/m, 70 kV/m) and three levels of bloodstream velocity (λinl).
• Compares two distinct pharmacokinetic profiles (One-short tri-exponential TPK and uniform UPK) for drug delivery.
• Results are derived from a previously developed, calibrated, and validated meshless computational code.

Limitations

• Data is presented as a 4.7 MB PDF, not a structured tabular dataset, limiting direct computational analysis.
• Sample data and column definitions are unavailable, requiring manual extraction for quantitative modeling.
• The dataset is small in scale and contains the results of a specific simulation study, not a large observational corpus.

Provenance

Source

Fabián Mauricio Vélez Salazar via figshare.

Collection Method

In-house computational tools, including meshless numerical simulations and a Boolean model.

Time Range

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Freshness

Last updated March 2026.

Geography

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