Zotatifin Broad-Spectrum Antiviral Activity Data

Zotatifin demonstrated a >4-log10 reduction in Mayaro virus titers at 50 nM. This dataset likely contains results from cytotoxicity and antiviral activity assays across multiple cell lines and virus strains, supporting the compound's potential as a pan-antiviral drug. The data was published by Patricia Valdés-Torres on figshare in March 2026.

Use Cases

• Evaluating dose-dependent antiviral efficacy based on plaque-forming assay results
• Analyzing viral protein synthesis inhibition based on Western blot and immunofluorescence data
• Studying interferon pathway activation based on RT-qPCR analysis results
• Comparing compound tolerability based on cytotoxicity assay data

Strengths

• Results cover five virus families, including Mayaro, Chikungunya, Una, Zika, influenza A, vesicular stomatitis, and vaccinia viruses
• Data includes multiple assay types: MTT, plaque-forming, Western blot, immunofluorescence, and flow cytometry
• The dataset is openly available under a CC-BY-4.0 license

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is 812.4 KB, indicating a limited scope

Provenance

Source

figshare

Collection Method

Likely contains experimental data from cytotoxicity (MTT) and antiviral activity (plaque-forming, Western blot, immunofluorescence, flow cytometry) assays.

Freshness

Last updated 2026-03-19 06:25:55; freshness should be verified