Bruceine D Effects on Prostate Cancer Cells: Transcriptomic and In Vivo Data

Data from a study investigating the anticancer effects of Bruceine D on prostate cancer cell lines PC-3 and C4-2B. The dataset includes results from assays measuring proliferation, migration, invasion, apoptosis, RNA sequencing, and a subcutaneous xenograft model in nude mice. It was authored by Zhiwei Chen and last updated on June 1, 2026.

Use Cases

• Analyze gene expression changes based on RNA sequencing results mentioned in the description
• Validate drug effects on cell proliferation and motility based on CCK-8, wound healing, and Transwell assay data
• Study protein expression levels based on Western Blotting results for targets like p-PI3K, p-AKT, and CXCL16
• Evaluate in vivo antitumor efficacy and toxicity based on the subcutaneous xenograft model results

Strengths

• Includes in vivo model data showing an 87.4% reduction in tumor volume at a 0.7 mg/kg dose
• Combines multiple experimental methods: transcriptomics, molecular docking, and flow cytometry

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Experimental data generated from laboratory assays and animal models.

Freshness

Last updated 2026-06-01 07:46:43