Caerin 1.1/1.9 Peptides: Antibacterial and Immunomodulatory Effects Against A. baumannii

A research article details the dual-action mechanisms of caerin peptides against multidrug-resistant Acinetobacter baumannii. The study includes in vitro A549 epithelial infection models and an in vivo murine skin-injury infection model, with results from MIC assays, CFU counts, flow cytometry, and cytokine profiling. The dataset, authored by Hongyin Wu and last updated in May 2026, is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing peptide efficacy based on MIC and CFU reduction data mentioned in the description
• Studying host immune cell responses based on flow cytometry and cytokine profiling results
• Modeling infection outcomes based on in vitro and in vivo model data described
• Investigating immunomodulatory mechanisms based on macrophage phenotype shift and cytokine changes

Strengths

• Includes data from both in vitro (A549 cells) and in vivo (murine) infection models
• Reports specific quantitative results, such as an MIC of 3.75 μg/mL
• Measures multiple immune parameters, including macrophage infiltration, neutrophil accumulation, and cytokine levels

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is contained within a PDF file, which may require extraction for computational analysis

Provenance

Source

figshare

Collection Method

Experimental data from infection models, antibacterial assays, and immune profiling.

Freshness

Last updated 2026-05-14 05:43:27; freshness should be verified