Cardiac Ventricular Kir6.1 K-ATP Channel Data on Cardioprotection

Sean Brennan's research article investigates the role of Kir6.1-containing ATP-sensitive potassium (K-ATP) channels in cardioprotection. The 295.6 KB PDF, last updated in April 2026, presents experimental results from patch-clamp recordings, metabolic inhibition, and coronary ligation protocols. Findings suggest these channels modulate action potential duration and calcium accumulation during metabolic stress.

Use Cases

• Analyzing the functional distinction between Kir6.1 and Kir6.2 K-ATP channel populations based on the experimental results described.
• Investigating the correlation between Kir6.1 channel activity and inherent cardioprotection in female-derived cardiomyocytes mentioned in the results.
• Supporting drug development pipeline assessments where channel block may inhibit endogenous cardioprotection, as suggested in the discussion.

Strengths

• Dataset is a structured research article with a clear experimental methodology described.
• Released under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.
• Specific findings on Kir6.1 channel activity and action potential shortening are detailed.

Limitations

• The dataset is a single 295.6 KB PDF document, which is a very small and limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

Sean Brennan, published on figshare.

Collection Method

Patch-clamp recordings, metabolic inhibition and washout experiments, and whole-heart coronary ligation protocols.

Time Range

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Freshness

Last updated 2026-04 20 04:13:23; freshness should be verified.

Geography

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