Cardiomyocyte-BDNF-KO Single-Nuclei RNA Sequencing Data for Cardiac Fibrosis Study

Single-nuclei RNA sequencing data from a study investigating the role of cardiomyocyte-derived BDNF in cardiac fibrosis. The dataset, published by Yu Zhu on figshare in 2026, includes results from bioinformatics analyses like KEGG and Gene Ontology. It is associated with functional studies using techniques such as qPCR, WB, and flow cytometry.

Use Cases

• Identify cell type composition changes in cardiac tissue based on single-nuclei RNA sequencing data mentioned in the description.
• Analyze pathway activity, such as the TGF-β/Smad2/3 pathway, using KEGG and Gene Ontology analysis results.
• Investigate cell-cell interaction networks in cardiac fibrosis models derived from the described snRNA-seq data.
• Validate gene expression signatures for cardiac fibroblasts and myofibroblasts using the provided sequencing data.

Strengths

• Data is associated with a detailed experimental methodology described in the publication, including snRNA-seq, KEGG, and functional assays.
• The dataset is licensed under CC-BY-4.0, allowing for open sharing and adaptation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 5.0 MB file size suggests the dataset may be a processed summary or subset rather than raw sequencing reads.

Provenance

Source

figshare, author Yu Zhu.

Collection Method

Data generated from single-nuclei RNA sequencing (snRNA-seq) and subsequent bioinformatics and functional analyses on mouse models.

Freshness

Last updated 2026-04-28 05:27:52; freshness should be verified.