Case Report: Cadonilimab-Induced Multiorgan Adverse Events and Rechallenge

A single clinical case report authored by Zhan Peng, uploaded on May 20, 2026. It details a 70-year-old female patient with metastatic gastric-type endocervical adenocarcinoma who developed sequential immune-related adverse events (cystitis, adrenal insufficiency, diabetic ketoacidosis) following cadonilimab therapy and subsequent successful rechallenge.

Use Cases

• Analyzing the timeline and management of sequential multiorgan adverse events based on the detailed case narrative
• Studying rechallenge feasibility and outcomes after resolution of severe immune-related adverse events based on the reported 24 cycles and 17-month progression-free survival
• Investigating rare adverse event presentations like immune-related cystitis and diabetic ketoacidosis based on the specific clinical findings described

Strengths

• Provides a detailed, longitudinal clinical narrative spanning nine months of treatment and follow-up
• Includes specific clinical metrics such as grade II cystitis, grade III adrenal insufficiency, and grade IV diabetes mellitus

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

Zhan Peng

Freshness

Last updated 2026-05-20 05:46:07; freshness should be verified