Case Report: Synchronous Colorectal Cancers with Discordant Mismatch Repair Status

A 116.6 KB PDF case report published on figshare by Daming Chen on 2026-04-27. It details a single case of synchronous colorectal adenocarcinomas with discordant mismatch repair status in a 67-year-old female patient. The report includes results from histopathology, immunohistochemistry, BRAF mutation testing, germline sequencing, and MLH1 promoter methylation analysis.

Use Cases

• Study the co-occurrence of distinct tumorigenic pathways (Lynch-like syndrome and serrated pathway) in a single patient based on the case description.
• Analyze the clinical workflow for lesion-specific molecular characterization combined with lymph node phenotyping as described in the report.
• Reference the diagnostic and treatment framework for managing synchronous colorectal cancers with heterogeneous mismatch repair status.
• Examine the correlation between MMR status in primary tumors and metastatic lymph nodes to infer metastatic potential.

Strengths

• Includes detailed molecular analysis results for a single, well-documented case, such as MMR IHC, BRAF V600E status, and germline NGS.
• Provides a 24-month clinical follow-up with patient outcome data.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a single case report (n=1), limiting statistical power and generalizability.
• Row count and column-level documentation are unknown; the data is embedded within a narrative PDF.
• The 116.6 KB size indicates a very limited scope, containing primarily textual case details rather than a structured dataset.

Provenance

Source

figshare

Collection Method

Clinical case study involving sequential imaging, colonoscopy, histopathology, and systematic molecular analyses.

Time Range

Case study period and a 24-month follow-up; specific dates not provided.

Freshness

Last updated 2026-04-27 04:14:29; freshness should be verified.