Data Sheet 1_Causal interplay between lactose intolerance and gut microbiota: a combined b

Data Sheet 1_Causal interplay between lactose intolerance and gut microbiota: a combined bidirectional Mendelian randomization and in vivo validation study.zip contains data from a study integrating genetic inference with experimental validation. The dataset includes summary statistics from the MiBioGen Consortium and the FinnGen study, validated by 16S rRNA sequencing from a rat model. Author Mengxiong Lu last updated the dataset on 2026-06-01.

Use Cases

• Validate causal links between specific bacterial taxa and lactose intolerance based on Mendelian Randomization results.
• Train models to predict microbial biomarkers for lactose intolerance using genetic and sequencing data.
• Compare human genetic associations with experimental animal model findings for gut microbiota composition.

Strengths

• Dataset integrates genetic summary statistics from two large consortiums (MiBioGen and FinnGen).
• Findings are validated with in vivo experimental data from a rat model using 16S rRNA sequencing.
• The study employs multiple robustness checks including inverse-variance weighted, MR-Egger, and sensitivity analyses.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is relatively small at 20.8 MB, potentially limiting the scope of analysis.

Provenance

Source

MiBioGen Consortium and FinnGen study for genetic data; experimental data from a lactose-intolerant rat model.

Collection Method

Two-sample bidirectional Mendelian Randomization analysis combined with 16S rRNA high-throughput sequencing.

Freshness

Last updated 2026-06-01 05:35:59; freshness should be verified.