AIGA Immunological Study: Cytokine Profiles and Skin Biopsy Findings

A 2026 study by Shingo Takei investigates the immune mechanisms of Acquired Idiopathic Generalized Anhidrosis (AIGA). The dataset likely contains research findings from 14 patients, including serum cytokine levels and skin biopsy immunohistochemistry results. The work is published on figshare under a CC-BY-4.0 license.

Use Cases

• Identify potential serum biomarkers for AIGA diagnosis based on elevated CCL22 and IFN-γ levels mentioned in the description
• Investigate the macrophage–CCL22–Th1 inflammatory axis in sweat duct pathology described in the study
• Predict steroid therapy responsiveness in AIGA patients based on serum MIF levels as suggested in the conclusions
• Correlate histological findings of periductal CD4+ T cell infiltration with systemic cytokine profiles

Strengths

• Study includes data from 14 AIGA patients with more than 25% body surface area affected.
• Analysis incorporates multiple methods: serum profiling of 40 cytokines/chemokines and skin biopsy immunohistochemistry.
• Findings propose a specific inflammatory axis and a potential biomarker (MIF) for steroid resistance.

Limitations

• Dataset is very small at 21.7 KB; the primary content is a research document, not a large-scale data table.
• Column-level documentation is absent; field semantics must be inferred from the research paper.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare, author Shingo Takei.

Collection Method

Clinical study involving patient serum analysis and skin biopsies.

Time Range

Study published in 2026.

Freshness

Last updated 2026-05 08 05:54:02.

Geography

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