Data Sheet on Tranexamic Acid's Cell-Dependent Antithrombotic Effects in Mice

Tranexamic acid reduced the odds of venous thrombus formation by 90% in a murine model without endothelial injury. The research includes measurements of plasma VWF:Ag and MCP-1 by ELISA, thrombin generation assays, and tail bleeding tests. Kata Balog Virág authored this 348.9 KB document, last updated on 2026-05-26.

Use Cases

• Analyzing the cellular mechanisms of tranexamic acid based on thrombin generation assays in whole blood versus platelet-rich plasma.
• Studying the relationship between plasminogen activity and thrombosis based on leukocyte surface-mediated plasminogen activation assays.
• Investigating the impact of TXA on inflammatory markers in thrombosis based on MCP-1 suppression results.
• Evaluating drug effects on primary hemostasis based on tail bleeding time data.

Strengths

• Includes specific quantitative results, such as a 90% reduction in thrombus formation odds.
• Describes a multi-method experimental approach including in vivo modeling, ELISA, and functional assays.
• Document is under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a 348.9 KB DOCX file, which is a very small text document, not a structured data table.
• Row count and column-level documentation are absent; data semantics must be inferred from the narrative.
• The description is detailed but the underlying raw numerical or tabular data is not directly accessible.

Provenance

Source

figshare

Collection Method

In vivo murine venous thrombosis model (IVC stenosis) with associated laboratory assays (ELISA, thrombin generation, plasmin generation, tail bleeding).

Freshness

Last updated 2026-05-26 04:39:09.