Data Sheet 1: DDX3X and DDX3Y Regulation in HCT116 and U87MG Cancer Cell Lines

A 4.0 MB document authored by Xiaolu Xu and last updated March 2026. It details experimental findings on the cell type-dependent cross-regulation between the RNA helicase paralogs DDX3X and DDX3Y in two male-derived human cancer cell lines.

Use Cases

• Study compensatory gene upregulation mechanisms based on DDX3Y mRNA and protein level changes.
• Analyze cell type-specific post-transcriptional regulation based on DDX3Y protein stability data.
• Investigate protein-protein interactions between X- and Y-linked paralogs based on the described physical interaction of DDX3X and DDX3Y.
• Model total DDX3 dosage control in development and disease based on the described cross-regulation.

Strengths

• Data is associated with a specific, peer-reviewed research context on DDX3X and DDX3Y.
• File size is 4.0 MB, indicating a manageable download.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count and column-level documentation are absent; data structure must be inferred after download.
• The dataset is a single 4.0 MB document, which may limit analytical scope.

Provenance

Source

figshare, author Xiaolu Xu.

Collection Method

Likely contains experimental data from molecular biology assays in HCT116 and U87MG cell lines.

Time Range

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Freshness

Last updated 2026-03-18 07:41:35.

Geography

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