Cerebrospinal Fluid Proteomics for Hydrocephalus Biomarker Discovery

An exploratory proteomic study of cerebrospinal fluid samples from 11 participants, including patients with post-hemorrhagic hydrocephalus, idiopathic normal pressure hydrocephalus, and non-hydrocephalus controls. The dataset was created by Hao Han and last updated on 2026-05-29. It compares protein-abundance patterns to identify candidate biomarkers like calcyphosine and follistatin-like 1.

Use Cases

• Identify differentially expressed proteins in hydrocephalus subtypes based on proteomic profiles.
• Validate exploratory candidate biomarkers like calcyphosine (CAPS) and follistatin-like 1 (FSTL1) in independent cohorts.
• Perform functional annotation analysis using pathways like Gene Ontology, KEGG, and Reactome mentioned in the description.
• Compare protein-abundance patterns between post-hemorrhagic hydrocephalus and idiopathic normal pressure hydrocephalus.

Strengths

• Dataset is 4.4 MB in size, facilitating quick download and local analysis.
• All samples passed quality-control criteria as stated in the description.
• Includes validation step via ELISA in an expanded cohort, supporting the proteomic findings.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study is exploratory with a small cohort of 11 participants, as noted in the description.

Provenance

Source

figshare

Collection Method

Cerebrospinal fluid samples analyzed using Olink proximity extension assay proteomics, with ELISA validation.

Freshness

Last updated 2026-05-29 07:14:55; freshness should be verified.