Cerebrovascular Phenotype Analysis in Gucy1a3 Knockout Mice for Moyamoya Disease Research

A figshare dataset by Pingkai Wang, last updated in April 2026, containing experimental results from a study on Gucy1a3 loss-of-function mice. The 54.1 KB Excel file likely holds quantitative measurements from magnetic resonance angiography, vascular casting, and histopathological evaluations. The data was generated to investigate the role of the GUCY1A3 gene in moyamoya disease susceptibility.

Use Cases

• Statistical analysis of vascular branching and density differences between knockout and wild-type mice based on reported metrics.
• Modeling the relationship between GUCY1A3 gene function and small-vessel integrity based on cortical microvessel measurements.
• Comparative analysis of leptomeningeal vascular network topology using skeletonization data mentioned in the description.
• Correlating histopathological staining results (H&E, EVG, α-SMA) with quantitative vascular metrics.

Strengths

• Includes specific quantitative results, such as reduced vascular branching (365.90 ± 14.92 vs. 330.00 ± 9.72) and density metrics with p-values.
• Data is derived from multiple experimental methods: 7.0T MRA, vascular casting, and multiple histopathological stains.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• The dataset is very small (54.1 KB), indicating limited scope, likely containing summary results rather than raw observations.
• Data is from a specific mouse model study; applicability to human moyamoya disease may be limited.

Provenance

Source

Pingkai Wang via figshare.

Collection Method

Experimental data from Gucy1a3−/− and wild-type mice using MRA, vascular casting, and immunohistochemistry.

Time Range

Study focused on early adult mice (8–12 weeks).

Freshness

Last updated 2026-04-13 04:35:50; freshness should be verified.

Geography

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