Klebsiella Aerogenes Strain S_KLB: Characterization and Pathogenic Mechanisms

A Klebsiella aerogenes strain S_KLB was isolated from a deceased ground thrush. The dataset, authored by Mingao Sun and uploaded on 2026-05-12, describes the strain's cultural characteristics, multidrug resistance profile, virulence genes, and its pathogenic effects in a murine pneumonia model.

Use Cases

• Study antibiotic resistance patterns based on the described resistance to imipenem and oxacillin.
• Analyze virulence gene profiles based on the described presence of siderophore, fimbriae, efflux pump, and metabolic factor genes.
• Investigate host-pathogen interactions based on the described murine pneumonia model and associated inflammatory responses.
• Model signaling pathway activation in infection based on the described upregulation of NF-κB, STAT3, and p38 MAPK pathways.

Strengths

• The description provides specific experimental results, including resistance to imipenem and oxacillin.
• The dataset details a specific murine model for acute pneumonia, including clinical and histopathological outcomes.
• Molecular mechanisms are described, including upregulation of TNF-α, IL-6, IL-1β, CXCL1, and Cleaved Caspase-3.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Laboratory study of an isolated bacterial strain.

Freshness

Last updated 2026-05-12 05:43:31; freshness should be verified.