ANXA1 in HNSCC Chemotherapy Resistance: Bulk and Single-Cell Profiles from TCGA and GEO

A bioinformatics analysis dataset investigating the role of the ANXA1 gene in chemotherapy resistance for head and neck squamous cell carcinoma. The data includes bulk patient profiles from the TCGA-HNSCC cohort and GEO datasets GSE6631 and GSE65858, as well as single-cell data from GSE163872. The study, authored by Ling Zheng and published under a CC-BY-4.0 license, was last updated in March 2026.

Use Cases

• Building predictive models for chemotherapy resistance based on identified differentially expressed genes.
• Identifying prognostic biomarkers for head and neck cancer patient risk stratification.
• Analyzing molecular and immune characteristics of a hub gene at bulk and single-cell levels.
• Performing AI-driven molecular docking for therapeutic agent discovery.

Strengths

• Integrates multiple public data sources, including TCGA and GEO cohorts.
• Analysis spans bulk and single-cell resolution levels.
• Includes validation of predictive models in an independent patient cohort (GSE65858).

Limitations

• Dataset is a 55.5 KB PDF, suggesting it contains analysis results rather than raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

TCGA and GEO databases (TCGA-HNSCC, GSE6631, GSE65858, GSE163872).

Collection Method

Bioinformatics analysis using Limma, WGCNA, and LASSO–Cox regression frameworks.

Time Range

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Freshness

Last updated 2026-03-18 07:44:40; freshness should be verified.

Geography

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