Endometrial Renin-Angiotensin System Gene Expression Across Menstrual Cycle Phases

A study by Tess L. Symington characterizes the expression of renin-angiotensin system components across the human endometrial cycle. The dataset includes qPCR mRNA quantification and immunohistochemistry protein localization data from 30 tissue samples collected during proliferative, mid-secretory, and late-secretory phases. It was last updated on 2026-04-28 and shared under a CC-BY-4.0 license.

Use Cases

• Analyzing phase-dependent mRNA expression patterns for REN, ATP6AP2, and AGT genes based on qPCR data.
• Investigating cell-type-specific protein localization of prorenin, prorenin receptor, and angiotensinogen based on immunohistochemistry results.
• Modeling the potential regulatory role of the renin-angiotensin system in stromal regeneration and proliferation.
• Correlating gene and protein expression data with hormonal changes across the menstrual cycle.

Strengths

• Includes data from 30 endometrial tissue samples (10 per cycle phase).
• Combines quantitative qPCR mRNA data with spatial protein localization from immunohistochemistry.
• Analysis performed using HALO image analysis software for quantification.

Limitations

• The dataset is small at 454.7 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Endometrial tissue collection, qPCR, and immunohistochemistry.

Freshness

Last updated 2026-04-28 04:29:15; freshness should be verified.