ChREBPα: Lipid Droplet Renewal in Preimplantation Mouse Embryos

Abdul Majid Khan's research dataset, last updated in April 2026, contains transcriptomic and imaging data from a study of lipid droplet regeneration in early mouse embryos. The data supports findings on the role of the ChREBP transcription factor as a metabolic sensor. The dataset is a 522.5 KB PDF file available under a CC-BY-4.0 license on figshare.

Use Cases

• Analyzing transcriptional responses to lipid depletion based on RNA sequencing data from 2-cell stage embryos.
• Studying the subcellular localization of ChREBP protein in relation to lipid droplet biogenesis based on immunofluorescence microscopy data.
• Investigating the functional role of ChREBP in embryonic survival based on inhibitor studies and developmental progression rates.

Strengths

• Dataset is associated with a detailed, peer-reviewed-style methodology section describing experimental procedures.
• The data is openly available under a permissive CC-BY-4.0 license.

Limitations

• The primary data format is a PDF, which may require extraction or manual transcription for computational analysis.
• The dataset is small (522.5 KB), suggesting it contains summary results or a data sheet rather than raw, large-scale data files.
• Column-level documentation and sample data are unavailable, limiting assessment of data structure.

Provenance

Source

figshare, author Abdul Majid Khan.

Collection Method

Data was generated from experiments on mouse zygotes, including mechanical delipidation, RNA sequencing, immunofluorescence microscopy, and functional inhibitor studies.

Freshness

Last updated 2026-04-23 05:35:36.