Data Sheet 1_circPVT1: Study on circRNA Regulation of RCC Immune Evasion

A 957.8 KB research document authored by Minhao Zhang and last updated in April 2026 details findings on the circular RNA circPVT1 in renal cell carcinoma. The study analyzes circPVT1 expression, its correlation with poor prognosis, and its role in promoting epithelial-mesenchymal transition and macrophage polarization. It includes results from single-cell sequencing, ELISA assays measuring IL-4, IL-10, and TGF-β secretion, and tests of a nanotherapeutic inhibitor system.

Use Cases

• Study the association between circRNA expression and cancer prognosis based on analyzed RCC samples.
• Investigate the role of circRNAs in modulating tumor-associated macrophage polarization based on single-cell sequencing and cytokine secretion data.
• Explore potential RNA-based therapeutic targets for renal cell carcinoma based on the tested nanotherapeutic inhibitor system.

Strengths

• The document provides a detailed methodological account including single-cell sequencing and ELISA assays.
• Findings are linked to concrete biological mechanisms like EMT regulation and cytokine secretion changes.
• The associated license is CC-BY-4.0, permitting broad reuse.

Limitations

• The primary data (e.g., sequencing reads, cell counts) is not directly available, only the summary document.
• Column-level documentation for any underlying data is absent; field semantics must be inferred.
• Row count for any potential underlying datasets is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Minhao Zhang

Collection Method

Research study involving analysis of RCC samples, in vitro experiments, single-cell sequencing, and ELISA.

Freshness

Last updated 2026-04-21 05:34:15; freshness should be verified.