Sarcopenia Biomarker Study of 325 Older Adults

A 2026 case-control study of 325 older adults (64 sarcopenia cases, 261 controls) investigates serum selectin levels as potential biomarkers. The research measures circulating E-selectin, L-selectin, and P-selectin concentrations via ELISA and analyzes their diagnostic utility for sarcopenia using ROC curves and logistic regression.

Use Cases

• Analyze the association between P-selectin levels and sarcopenia diagnosis using logistic regression models on 325 participant records.
• Assess the diagnostic utility of serum P-selectin concentrations via ROC curve analysis against the Asian Working Group for Sarcopenia 2019 criteria.
• Examine relationships between selectin levels and clinical measures like appendicular muscle mass and handgrip strength.
• Compare circulating E-selectin and L-selectin levels between sarcopenia cases and control groups.

Strengths

• Case-control design with 325 participants provides a clear comparative structure.
• Includes specific biomarker measurements (P-selectin, E-selectin, L-selectin) with reported concentrations and statistical results.
• Diagnostic analysis provides concrete metrics like an AUROC of 0.693 and an optimal P-selectin cutoff of 17.28 ng/mL.

Limitations

• Data is presented in a PDF report (379.1 KB), not in a structured, machine-readable tabular format.
• Sample size of 64 sarcopenia cases may limit the generalizability of findings.
• Geographic and demographic specifics of the participant cohort are not provided.

Provenance

Source

Hu Zhang via figshare.

Collection Method

Case-control study; serum selectin concentrations measured by ELISA.

Time Range

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Freshness

Last updated March 2026.

Geography

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