MARCoNS and Neuroendocrine Biomarkers in Chronic Inflammatory Response Syndrome Patients

Margaret DiTulio's dataset contains longitudinal biomarker measurements from 188 adult patients evaluated for Chronic Inflammatory Response Syndrome (CIRS). The data includes two timepoints for α-MSH, MMP-9, and VIP levels, along with culture results for multiple antibiotic-resistant coagulase-negative staphylococci (MARCoNS). This retrospective observational cohort study was last updated in April 2026.

Use Cases

• Modeling the association between MARCoNS clearance and α-MSH trajectory based on the described interaction effect.
• Analyzing longitudinal changes in MMP-9 and VIP levels in a CIRS patient cohort.
• Training classifiers to predict MARCoNS culture status from biomarker profiles mentioned in the study.
• Conducting secondary analysis on the selective relationship between bacterial colonization and specific neuroimmune peptides.

Strengths

• Includes paired longitudinal data from two timepoints for 188 patients.
• Measures three specific biomarkers (α-MSH, MMP-9, VIP) alongside clinical culture results.
• Dataset is associated with a detailed methodological description in the source PDF.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data tables is unknown, which may limit suitability assessment.
• Data reflects a single clinical site and a specific patient population, which may limit generalizability.

Provenance

Source

Margaret DiTulio via figshare

Collection Method

Retrospective observational cohort study from a single clinical site.

Freshness

Last updated 2026-04-17 04:12:00; freshness should be verified.