Clinical Outcomes of Oral Cavity Flap Reconstruction with Animal Model Comparison

Clinical data evaluates tunnelized-facial artery myomucosal island flaps (t-FAMMIF) for oral cancer reconstruction versus cutaneous flaps. The study includes outcomes for 23 t-FAMMIF patients, with 20 matched pairs for comparison, and incorporates a beagle dog model for histological analysis. Author Zengyu Chen published this work in April 2026.

Use Cases

• Compare sensory outcomes like Semmes-Weinstein monofilament test and two-point discrimination scores between t-FAMMIF and cutaneous flap patient groups.
• Analyze motor function recovery using Water Swallowing Test results and maximum inter-incisal opening measurements across postoperative time points.
• Correlate facial nerve function assessed via House-Brackmann grading scale and wireless surface electromyography with flap type.
• Investigate histological differences in scar formation and salivary gland preservation between mucosal and cutaneous flaps using the beagle dog model data.

Strengths

• Includes matched patient cohorts with 20 cases per group for controlled clinical comparison.
• Integrates histological data from an animal model to explain clinical findings on tissue-level mechanisms.
• Assesses multiple functional domains: sensory, motor, nerve function, and aesthetics with specific tests.

Limitations

• Small clinical sample size of 23 primary patients limits statistical power for broader generalization.
• Dataset scope is limited to a single surgical technique comparison, not a broad registry of oral reconstruction methods.
• Primary data is embedded in a narrative document (DOCX), requiring extraction for quantitative analysis.

Provenance

Source

figshare, authored by Zengyu Chen.

Collection Method

Clinical study of enrolled patients and controlled animal model experiment with histological analysis.

Time Range

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Freshness

Last updated April 2026.

Geography

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