RRN3 Pan-Cancer Analysis: Expression, Clinical Associations, and Functional Validation

A 4.0 MB dataset from figshare, authored by Ruofan He and last updated in May 2026, provides data from a study on the nucleolar protein RRN3. The analysis includes RRN3 expression levels, clinicopathological associations, survival outcomes, genomic alterations, immune-related features, and drug-response profiles across multiple cancers, with a focus on gastric cancer. Experimental validation data from in vitro and in vivo assays is also included.

Use Cases

• Correlate gene expression with clinical outcomes based on survival analysis data
• Identify immune-related signatures based on immune cell infiltration and checkpoint gene associations
• Assess drug-response profiles based on drug-response-related signatures mentioned in the description
• Validate gene function in cancer progression based on in vitro and in vivo experimental data

Strengths

• Includes experimental validation data from in vitro rescue experiments and in vivo xenograft assays
• Analyzes multiple data dimensions: expression, survival, genomic alterations, immune features, and drug response
• Focuses on a specific cancer type (gastric cancer) with clinical tissue validation

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect the specific analytical and experimental bias inherent to the original study

Provenance

Source

figshare

Collection Method

Analysis of public databases combined with original experimental validation

Freshness

Last updated 2026-05-22 04:29:12; freshness should be verified