Coagulation Markers and Kidney Function in South African HIV Patients

Joel Choshi's research dataset, last updated on 2026-05-22, investigates associations between coagulation markers and renal function in people living with HIV. The dataset is derived from a cross-sectional study of 151 adults in South Africa, comprising 80 PLWH on ART, 27 PLWH not on ART, and 44 people not living with HIV. It includes measurements of inflammatory and coagulation markers (C-reactive protein, fibrinogen, D-dimer) and estimated glomerular filtration rate based on cystatin C.

Use Cases

• Analyzing associations between coagulation markers (D-dimer, fibrinogen) and kidney function decline based on eGFRcystC measurements.
• Investigating differences in biomarker profiles between HIV patients on antiretroviral therapy and those not on therapy.
• Modeling the risk of chronic kidney disease using coagulation and inflammatory markers as predictors.
• Comparing renal function and biomarker levels between people living with HIV and a control group of people not living with HIV.

Strengths

• Includes a control group of 44 people not living with HIV for comparative analysis.
• Provides specific p-values and adjusted odds ratios for key associations, such as D-dimer with reduced eGFRcystC (p=0.004).
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (61.5 KB), indicating a limited scope and sample size of 151 participants.

Provenance

Source

figshare, author Joel Choshi.

Collection Method

Cross-sectional study with biomarker measurements and clinical assessment.

Time Range

null

Freshness

Last updated 2026-05-22 05:34:39; freshness should be verified.

Geography

South Africa