Collagen-Mediated MAPK Activation in Solid Cancers: Transcriptomic and Clinical Analysis

A research article analyzing transcriptomic data from public databases and in-house clinical samples to explore collagen deposition in gastric and lung cancers. The study, authored by Junli Ding and last updated in March 2026, investigates correlations with clinical outcomes, tumor microenvironment components, and MAPK signaling pathways. The findings were validated through in vitro and in vivo functional assays.

Use Cases

• Study the correlation between collagen deposition and poor clinical outcomes in gastric cancer based on the described analysis.
• Investigate the relationship between collagen and angiogenesis via vascular endothelial cell abundance mentioned in the results.
• Analyze collagen's role in immunosuppression through its correlation with M2-polarized macrophages as described.
• Explore the activation of the MAPK signaling pathway by collagen for tumor progression modeling.
• Validate findings across cancer types using the described confirmation in lung cancer.

Strengths

• Includes validation through in vitro and in vivo assays as described in the methods.
• Analyzes data from both public databases and in-house clinical samples, suggesting a multi-source approach.
• Released under a permissive CC-BY-4.0 license for reuse.
• Last updated on 2026-03-17, indicating recent maintenance.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The primary data file is a 3.2 MB DOCX document, which may require extraction or conversion for computational analysis.
• The dataset's scale is small (3.2 MB), which may limit the amount of raw data available.

Provenance

Source

figshare, authored by Junli Ding.

Collection Method

Analysis of transcriptomic data from public databases and in-house clinical samples, with in vitro and in vivo validation.

Time Range

The study's temporal coverage is not specified.

Freshness

Last updated 2026-03-17 13:06:07

Geography

The geographic scope of the clinical samples is not specified.