Mitophagy Key Genes in Immune Checkpoint Inhibitors-Related Myocarditis

Four mitophagy key genes (AW112010, Igfbp7, Tmsb4x, Ost4) identified as potential biomarkers for immune checkpoint inhibitors-related myocarditis. The dataset was generated by combining single-cell RNA sequencing and bulk RNA sequencing data, with validation in a mouse model. It was authored by Jian Yu and last updated on 2026-04-21.

Use Cases

• Validate diagnostic biomarkers for ICIs-related myocarditis based on the identified mitophagy key genes.
• Analyze gene expression patterns in cardiac immune cells using the single-cell RNA sequencing data mentioned in the description.
• Investigate correlations between mitophagy genes and myocardial injury markers (BNP, CK-MB, cTnT) or cardiac function indicators (LVEDV, LVEF).
• Study cell-cell interaction networks involving the key genes AW112010, Igfbp7, Tmsb4x, and Ost4.

Strengths

• Identifies four specific mitophagy key genes (AW112010, Igfbp7, Tmsb4x, Ost4) with reported statistical significance (P < 0.05 or P < 0.01).
• Validation includes multiple analysis levels: bioinformatics screening, single-cell validation, and a mouse model with qRT-PCR results.
• Dataset is openly shared under a CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset is small in scale (131.9 KB), suggesting limited raw data or processed results only.
• Description metadata is limited; actual data structure and quality require manual inspection after download.

Provenance

Source

figshare

Collection Method

Combined analysis of single-cell RNA sequencing and bulk RNA sequencing data, validated with a constructed mouse model.

Freshness

Last updated 2026-04-21 05:34:32; freshness should be verified.