Comparative DCMS Analysis Revealing an X-Linked Selection Signature in Changthangi Sheep

Sapna Nath's research dataset from 2026 contains genomic analysis results for three indigenous Indian sheep breeds. It includes data from 79 sheep genotyped with the Illumina OvineSNP50 BeadChip, applying a de-correlated composite of multiple signals approach. The analysis identified a candidate selection region on the X chromosome specific to the Changthangi breed.

Use Cases

• Identify candidate genes for high-altitude adaptation based on the reported X-linked selection signature in Changthangi sheep.
• Prioritize genes related to milk production, body weight, and reproduction using the annotated quantitative trait loci (QTLs).
• Analyze protein-protein interaction networks to understand functional relationships among candidate genes like OTUD5.
• Compare selection signatures across different sheep breeds (Changthangi, Deccani, Garole) using the integrated composite statistics.

Strengths

• Dataset applies a de-correlated composite of multiple signals approach integrating five individual statistics (FST, H1, H12, Tajima’s D, π).
• Analysis is based on a specific sample size of 79 sheep across three breeds (Changthangi n=29, Deccani n=24, Garole n=26).
• Results include a specific candidate genomic region on the X chromosome (~55.9–57.2 Mb; ~1.396 Mb) with 31 annotated genes.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 2.7 MB DOCX file, which may require parsing to extract structured data.

Provenance

Source

Sapna Nath via figshare

Collection Method

Genomic analysis using the Illumina OvineSNP50 BeadChip and the DCMS statistical approach.

Freshness

Last updated 2026-05-18 22:02:39; freshness should be verified.

Geography

India (focus on indigenous Changthangi, Deccani, and Garole sheep breeds)