Systematic Review Protocol for G-CSF Efficacy in Breast Cancer Chemotherapy

Xiaoyun Bi's protocol outlines a systematic review and network meta-analysis to compare short-acting and long-acting granulocyte colony-stimulating factors for preventing chemotherapy-induced myelosuppression in breast cancer patients. The study will search multiple databases, including PubMed and Chinese literature sources, for randomized controlled trials from inception to September 30, 2025. It will assess outcomes including myelosuppression incidence, chemotherapy relative dose intensity, overall survival, and adverse events.

Use Cases

• Conduct a network meta-analysis to rank the efficacy of different G-CSF formulations based on myelosuppression incidence and severity outcomes.
• Analyze the relationship between chemotherapy relative dose intensity and adverse events reported across the included randomized controlled trials.
• Assess the certainty of evidence for overall survival and infection-related mortality findings using the GRADE system.
• Evaluate the methodological quality of identified studies using the Cochrane Risk of Bias tool (V.2.0) as part of the review process.

Strengths

• Protocol defines a clear, structured methodology for a systematic review and network meta-analysis.
• Search strategy is comprehensive, covering major international and Chinese literature databases up to September 2025.
• Outcomes are clinically relevant, including myelosuppression incidence, chemotherapy dose intensity, survival, and safety.

Limitations

• The dataset is a protocol document (81.5 KB), not the resulting analysis data, limiting immediate analytical utility.
• The final evidence and rankings depend on the quality and availability of the underlying randomized controlled trials identified.
• Potential for language or publication bias as the review's findings are not yet available.

Provenance

Source

Xiaoyun Bi via figshare

Collection Method

Planned systematic review and network meta-analysis of randomized controlled trials.

Time Range

Literature search from database inception to September 30, 2025.

Freshness

Protocol last updated March 2026, but the underlying evidence search extends to September 2025.

Geography

Global, with specific inclusion of Chinese literature databases (CNKI, Wanfang, VIP, SinoMed).