Comparative Pharmacokinetics of Periplocin Metabolites in Rats After Oral Administration

Pharmacokinetic data compares the absorption and metabolism of periplocin and four key metabolites in rats following oral administration of pure periplocin versus a cardiac glycoside extract from Cortex Periplocae. The dataset was generated using an ultra-performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-TQ-S-MS/MS) method and was last updated on 2026-05-14. It was authored by Peng Zhao and shared under a CC-BY-4.0 license.

Use Cases

• Compare metabolite exposure levels (Cmax, AUC) between pure compound and complex extract administration.
• Analyze potential enterohepatic circulation based on double peaks in concentration-time curves.
• Model pharmacokinetic parameters like Tmax for periplocin and its metabolites.
• Investigate the influence of a herbal extract matrix on the bioavailability of active compounds.

Strengths

• Specific dosing information is provided: 50 mg/kg pure periplocin and 100 mg/kg extract (equivalent to ~52 mg/kg periplocin).
• Methodology is clearly described: a developed UPLC-TQ-S-MS/MS method was used.
• Key pharmacokinetic parameters are reported, including Tmax, Cmax, and AUC(0-∞).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (94.1 KB), indicating limited scope.

Provenance

Source

Peng Zhao via figshare

Collection Method

Data generated from a comparative pharmacokinetic study in rats using UPLC-TQ-S-MS/MS analysis.

Freshness

Last updated 2026-05-14 05:41:30; freshness should be verified.